Tag: 上海419龙凤VX


Gollob claims Danish win but Pedersen stays in front


first_imgFirst published on Sun 15 Jun 2008 19.01 EDT Speedway Jeremy Alexander Share on Twitter Gollob claims Danish win but Pedersen stays in front Sun 15 Jun 2008 19.01 EDT Topics Support The Guardian Share on Facebook Shares00 Share via Email Since you’re here… … we have a small favour to ask. The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.More people are reading and supporting The Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we have chosen an approach that allows us to keep our journalism accessible to all, regardless of where they live or what they can afford. But we need your ongoing support to keep working as we do.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We need your support to keep delivering quality journalism, to maintain our openness and to protect our precious independence. Every reader contribution, big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Tomasz Gollob became the first rider to win two world championship races this year when he took the Danish grand prix in Copenhagen, denying Nicki Pedersen a first win in his home event. By reaching the final of all four races, though, the Dane leads the overall standings by 11 points from the Pole.Indeed, such is the virtue of consistency through the heats, too, that overall Pedersen, the reigning champion, took a point more from the event than Gollob did for winning it. Britain’s riders did not fare well, Scott Nicholls finishing 10th and Chris Harris 15th. Both will be looking to raise their game in the next round, at the Millennium Stadium in Cardiff on June 28. Speedwaylast_img read more


Updated NIH says cancer study also hit by fetal tissue ban


first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country *Update, 13 December, 11:45 a.m.: A third laboratory at the National Institutes of Health (NIH) is also affected by the agency’s temporary ban on acquiring new human fetal tissue, an agency spokesperson confirmed last night. Initially, NIH said only research projects run by staff scientists at the National Eye Institute (NEI) and the National Institute of Allergy and Infectious Diseases (NIAID) would be affected. The third laboratory is at the National Cancer Institute (NCI), which is pursuing a “project on cancer immunotherapy, which will need tissue by January 31,” the agency said in a statement. “We are determining appropriate next steps to obtain tissue so that the NIAID project can begin and to avoid interruption of the NCI project. NEI does not have an immediate need to procure new fetal tissue (they have frozen stores).”Here is our story from 7 December:U.S. President Donald Trump’s administration has ordered scientists employed by the U.S. National Institutes of Health (NIH) to stop acquiring new human fetal tissue for experiments, ScienceInsider has learned. The suspension, imposed this past September without a public announcement, came as the government launched a review of all fetal tissue research funded by the federal government. The pause affects two laboratories run by the Bethesda, Maryland–based agency, NIH officials say. In one case, it disrupted a study probing how the virus that causes AIDS initially colonizes human tissues. National Institute of Allergy and Infectious Diseases/National Institutes of Health (CC BY-NC) Email “We were all poised to go and then the bombshell was dropped,” says HIV researcher Warner Greene, director of the Gladstone Center for HIV Cure Research in San Francisco, California, who was collaborating with an NIH laboratory that received the order. “The decision completely knocked our collaboration off the rails. We were devastated.”The order expands the scope of the Trump administration’s interventions into federally funded research that uses human fetal tissue from elective abortions, which is legal but fiercely opposed by antiabortion groups. In September, it canceled a Food and Drug Administration (FDA) contract for acquiring human fetal tissue for testing candidate drugs. This week, the Department of Health and Human Services (HHS), which oversees NIH, told researchers at the University of California (UC), San Francisco, that it would be extending a contract for work involving human fetal tissue for just 90 days instead of the usual 1 year, prompting media reports that the department was preparing to cancel the contract. HHS denied those reports, saying it has made no decisions regarding federal funding for human fetal tissue research pending the outcome of the ongoing review of all such work.Today, however, an NIH spokesperson confirmed that the agency asked staff scientists “to pause procurements of fetal tissue” pending the outcome of the HHS review. The suspension applies only to scientists who work directly for NIH’s intramural program, and not extramural researchers who typically work at universities and receive grants from the government. It affects two laboratories, NIH officials say. One is operated by the National Eye Institute. (Fetal retinal tissue is used to study eye diseases.) The other is run by the National Institute of Allergy and Infectious Diseases (NIAID). “Yes, we have instituted a pause of further procurements [of human fetal tissue] pending the audit/review that HHS is undertaking,” an NIAID spokeperson confirmed.The HIV experiment disrupted by the suspension was being conducted at NIAID’s Rocky Mountain Laboratories (RML) in Hamilton, Montana, which focus on infectious diseases. Researchers there use fetal tissue donated by women who have had legal abortions to create so-called humanized mice, which have immune systems that behave like a human’s. Humanized mice have played a key role in testing and developing treatments for HIV/AIDS. The NIH lab had, for several years, obtained the human fetal tissue from Advanced Bioscience Resources (ABR), based in Alameda, California. According to emails provided to ScienceInsider by Greene, RML researcher Kim Hasenkrug had prepared humanized mice for a trial of an antibody that the researchers believed—based on promising lab dish studies—might prevent HIV from establishing reservoirs in the human body. (Hasenkrug could not be reached for comment.) On 11 September, Hasenkrug informed Greene and Thomas Packard, a postdoctoral student of Greene’s, that he had obtained needed reagents and the mice were ready. Packard responded that they were excited at the prospect of getting the study started, and would immediately send Hasenkrug a batch of the antibodies. “I’ll not be able to get [the antibodies] on the 3 PM FedEx today, but I’ll ship [the antibodies] to you tomorrow, so you should have it on Thursday,” Packard wrote in an email.On 28 September, however, Greene received a message from Hasenkrug that left him stunned. The email, which bore the subject line “HHS directive,” read in part: Hasenkrug had not yet launched the experiment, Greene says, and his supplies of existing mice were too small to conduct the repeated experiments required to reach convincing scientific conclusions.The order to Hasenkrug came just as HHS launched its review of human fetal tissue research, and at the same time that the department killed the FDA contract, which was with ABR. (The department wrote at that time that it was “not sufficiently assured that the contract included the appropriate protections applicable to fetal tissue research,” but provided no evidence of violations.)It is unclear whether HHS will next place restrictions on the grants of NIH-funded investigators at universities who don’t work for NIH but whose projects also rely on access to new fetal tissue. ScienceInsider posed this question and others to Assistant Secretary of Health Brett Giroir, who is heading the review, but did not receive a response by press time. Some extramural scientists are concerned. “Everything I am doing involves humanized mice. It would shut my lab down if we were not able to use fetal tissues,” says Jerome Zack, a virologist who studies HIV at UC Los Angeles, and has been using humanized mice for 25 years.Such mice are particularly valuable for HIV drug testing in part because tissue from a single human fetus can readily generate a group of 40 to 50 genetically identical mice, and because the animals can, unlike monkeys, be infected with the human virus, HIV. Potential drugs can then be tested in such a group, with ample mice as controls, giving the studies robust statistical power.Packard calls the HHS review and its attendant constraints “really just a travesty for the outlook for HIV research. Mice made with human fetal tissue are critical to moving from discoveries in the lab to clinical treatments. Blocking this significantly hurts our chances of finding an HIV cure.”Greene adds that even if the HHS order is eventually lifted, the lost time would be consequential. “If we were given the green light right now” to resume acquiring fetal tissue, he says, “it would probably take us a year to get back in the position we were in when the ban was put in place.”After this story was published, NIH emailed an additional statement. It said the agency in September “put a pause in place” for staff scientists procuring new human fetal tissue, “an action NIH thought was prudent given the examination of these procurements. Research with tissue already on hand could proceed, and NIH leaders asked to be notified by intramural investigators if new procurement would be necessary. NIH leadership was not informed that new procurement was necessary for the study you reference in your story. We are looking into why this did not occur.”*Update, 8 December, 10 p.m.: This story has been updated to clarify a quote from Thomas Packard.*Update, 9 December, 9:30 a.m.: This story is updated with an additional statement that NIH provided after the story was published.*Update, 10 December, 11:30 a.m.: The story has been updated to clarify what kinds of treatments have benefited from research involving humanized mice. Updated: NIH says cancer study also hit by fetal tissue bancenter_img President Donald Trump’s administration ordered scientists at the federal Rocky Mountain Laboratories in Hamilton, Montana, ​to stop acquiring human fetal tissue, disrupting HIV experiments. Click to view the privacy policy. Required fields are indicated by an asterisk (*) [HHS] has directed me to discontinue procuring fetal tissue from ABR, the only source for us. I think that they are the only provider of fetal tissue for scientists in the nation who don’t have direct access to aborted fetal tissue. This effectively stops all of our research to discover a cure for HIV. By Meredith WadmanDec. 13, 2018 , 11:45 AM Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwelast_img read more